臨牀消化器内科 Vol.30 No.1(6-2)


特集名 消化器診療 ― 30年と今後の展望
題名 胆膵領域の変遷と展望 (2) 膵
発刊年月 2015年 01月
著者 下瀬川 徹 東北大学大学院医学系研究科消化器病態学分野
【 要旨 】 代表的な四つの膵疾患を取り上げ,過去30年間の変遷と今後の展望について述べた.本邦では,急性膵炎の患者数が急速に増加しているが,重症例の致命率は改善してきた.アトランタ分類の改訂により診療方針に新たな展開がみられる.慢性膵炎は遺伝性膵炎の原因遺伝子の発見をきっかけに,発症機序や早期病態に光が当てられるようになった.自己免疫性膵炎は本邦から提唱された疾患概念であり,国際コンセンサス診断基準の提唱により病態解析,診療方針について世界的な展開が期待される.本邦では膵癌患者が急増している.早期発見のためのスクリーニング法の開発,画期的な治療薬の開発など課題は多い.
Theme Clinical Gastroenterology -- Past 30 Years and Future Vision
Title History and Future of Pancreas
Author Tooru Shimosegawa Department of Gastroenterology, Tohoku University, Graduate School of Medicine
[ Summary ] In Japan, the number of patients with acute pancreatitis (AP) has been rapidly increasing. However, the prognosis of severe AP has been improved because of the advancements of treatment methods. The recently revised Atlanta Classification will have an impact on the therapeutic strategy of severe AP. The discovery of the genes responsible for hereditary pancreatitis and some types of idiopathic pancreatitis has shed light on the pathological mechanisms of chronic pancreatitis (CP) and its early clinical features. The prospective follow‒up of patients in the early stage of CP diagnosed using the Japanese Clinical Diagnostic Criteria 2009 is expected to clarify the clinical course and the best treatment for the prevention of disease progression. Since the proposal of the concept of autoimmune pancreatitis (AIP), the disease has attracted much attention in terms of the pathology, clinical features, and treatment. Although the international consensus diagnostic criteria (ICDC) for AIP have been proposed, the best therapeutic strategy has not yet been established. The number of patients with pancreatic cancer (PCa) has also been increasing rapidly in Japan. Despite some advances in the diagnosis and treatment, the prognosis of PCa has not remarkably improved in the past 30 years, necessitating epoch‒making advancement in this field.
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