| Theme |
The Roles of Gut Physiological Active Peptides in the Control of Nutrition and Metabolism |
| Title |
Role of Cholecystokinin (CCK) in Energy Balance Regulation |
| Author |
Kyoko Miyasaka |
Department of Physiology, Tokyo Kasei University. Graduate School of Human Life |
| Author |
Akihiro Funakoshi |
Department of Internal Medicine, Division of Pancreatology, Fukuoka Sanno Hospital, International University of Health and Welfare |
| [ Summary ] |
Cholecystokinin (CCK) is an important gastrointestinal hormone. It is one of the most abundant neurotransmitter peptides expressed in the brain. Two receptors［CCK-1(A) and CCK-2(B)］have been cloned. The CCK-2(B) receptor is derived from the same gene as the gastrin receptors. CCK is the first peptide discovered to induce satiety. The satiety effect produced by CCK may be mediated via CCK-1(A) receptors on the vagal afferent nerve terminals. The satiety signal originates in the hypothalamus. The CCK-1(A) receptor has been also reported to be involved in homeostasis of body temperature in response to changes in ambient temperature. Therefore, CCK and CCK-1(A) receptors are involved in both energy intake and energy expenditure. Regulation of CCK-1(A) receptor function may be useful to regulate food intake and prevent obesity. |