| Theme |
The Roles of Gut Physiological Active Peptides in the Control of Nutrition and Metabolism |
| Title |
Mechanisms of PP Family Peptides in Suppressing Food Intake and Clinical Applications |
| Author |
Minglun Tsai |
Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences |
| Author |
Akihiro Asakawa |
Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences |
| Author |
Akio Inui |
Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences |
| [ Summary ] |
The increase in the number of obese individuals and the number patients with metabolic syndrome, leading to diabetes, hypertension, dyslipidemia associated with obesity is becoming a serious public health concern not only in developed countries but also in some developing countries. Imbalances in energy intake and output may contribute to the mechanisms associated with the pathophysiology of obesity. Analyses of the mechanisms affecting appetite and weight regulating peptides such as ghrelin and pancreatic polypeptide (PP) family peptides are underway. PP and peptide tyrosine-tyrosine(PYY)decrease food intake and reduce body weight primarily via Y4 and Y2 receptors. Recently, it has been revealed that PYY3-36 modulates neural activity within both corticolimbic and higher-cortical areas as well as the homeostatic brain regions in humans. Understanding the mechanisms of appetite and body weight regulation which mediate brain and peripheral organs, including the gut, could lead to the development of new treatment methods for metabolic syndrome. |