| Theme |
The Roles of Gut Physiological Active Peptides in the Control of Nutrition and Metabolism |
| Title |
Role of Insulin in Control of Feeding |
| Author |
Daisuke Kohno |
Division of Integrative Physiology, Department of Physiology, Jichi Medical University |
| Author |
Fumihiko Maekawa |
Division of Integrative Physiology, Department of Physiology, Jichi Medical University |
| Author |
Yuko Maejima |
Division of Integrative Physiology, Department of Physiology, Jichi Medical University |
| Author |
Darambazar Gantulga |
Division of Integrative Physiology, Department of Physiology, Jichi Medical University |
| Author |
Toshihiko Yada |
Division of Integrative Physiology, Department of Physiology, Jichi Medical University |
| [ Summary ] |
Insulin is not only an antihyperglycemic hormone which rises postprandially but a feeding suppressant, acting in the hypothalamus. Recent studies have shown that insulin directly acts on hypothalamic neurons. Studies using conditional knockout mice have demonstrated that insulin actions in such neurons play an indispensable role in the control of feeding and energy metabolism. Furthermore, growing evidence indicates that insulin is related to hyperphagia in type 1 and type 2 diabetes. This review highlights recent findings regarding insulinʼs actions on the hypothalamic neurons which regulate feeding and metabolism. We primarily focus on the interaction of insulin with other hormonal signals such as leptin and ghrelin in NPY/AgRP and POMC neurons in the arcuate nucleus and nesfatin-1 neurons in the paraventricular nucleus. The impaired interaction of hormones in these neurons may lead to dysregulation of feeding and body weight. |