| Theme |
The Roles of Gut Physiological Active Peptides in the Control of Nutrition and Metabolism |
| Title |
The Mechanism for Appetite Regulation by Gastrointestinal Hormones |
| Author |
Koji Yakabi |
Department of Gastroenterology and Hepatology, Saitama Medical University, Saitama Medical Center |
| [ Summary ] |
Recent studies have demonstrated that many gut peptides play important roles in the regulation of appetite. Basically, the regulation of appetite is performed by several neural nuclei in the brain. The neural nuclei, which are primarily located in the hypothalamus create a network for the regulation of appetite. Neural peptides which have actions in relation to regulation are outlined. On the other hand, leptin and insulin act as peripheral adiposity signals and are known to have important roles in the regulation of appetite. These peptides stimulate or inhibit the activity of neurons in the central nervous system. The roles of gut hormones seem to modulate the work of systems which are produced in co-operation with the central neurons and adiposity signals. The actions of gut hormones seem to control short term appetite for hours at a time. Research in this area may produce new strategies for the treatment of obesity. |