| [ Summary ] |
Most cases of NASH develop due to obesity and lifestyle-related diseases. However, hypopituitarism, medications (such as tamoxifen), hypothyroidism, polycystic ovary syndrome, obstructive sleep apnea, hypogonadism, pancreaticoduodenectomies, and short bowel syndrome are also thought to be important risk factors for NASH or secondary NASH. We need to pay particular attention to young NASH patients with hypopituitarism and hypothalamic disorders, since their conditions can progress rapidly. For those young NASH patients with hypopituitarism, it has been reported that GH treatment is effective. These findings suggest that elucidation of the pathogenesis of secondary NASH may lead to a therapy for primary NASH. |