| Theme |
Obesity Related Digestive Diseases |
| Title |
Obesity and Cancer |
| Author |
Hirokazu Takahashi |
Department of Gastroenterology, Yokohama City University Hospital |
| Author |
Shiori Uchiyama |
Department of Gastroenterology, Yokohama City University Hospital |
| Author |
Eiji Yamada |
Department of Gastroenterology, Yokohama City University Hospital |
| Author |
Hidenori Ohkubo |
Department of Gastroenterology, Yokohama City University Hospital |
| Author |
Takuma Higurashi |
Department of Gastroenterology, Yokohama City University Hospital |
| Author |
Eiji Sakai |
Department of Gastroenterology, Yokohama City University Hospital |
| Author |
Hiroki Endo |
Department of Gastroenterology, Yokohama City University Hospital |
| Author |
Atsushi Nakajima |
Department of Gastroenterology, Yokohama City University Hospital |
| [ Summary ] |
Cancer accounts for 1/3 of the deaths in Japan. It is thought that obesity is a factor leading to the development of cancer. Obesity linked to increased cancer risk factors, such as disturbed insulin levels, as well as IGF-1 and leptin imbalances have been analyzed in detail. Mechanisms related to carcinogenesis or cancer progression have also been investigated. The PI3K/Akt signaling pathway is activated by insulin, IGF-1 and leptin. This is due to obesity. These factors have been revealed as potential therapeutic targets. AMP kinase and mTOR are affected by obesity, and key molecules which control energy consumption and survival. Gut microbiota and physical activity may be involved in the initiation or progression of several forms of cancer. |