| Theme |
Diagnosis and Treatment of Lower Gastrointestinal Tract Submucosal Tumors |
| Title |
The Diagnosis and Treatment of Colorectal Lymphomas |
| Author |
Tatsuo Yachida |
Endoscopy Division, National Cancer Center Hospital |
| Author |
Taku Sakamoto |
Endoscopy Division, National Cancer Center Hospital |
| Author |
Takeshi Nakajima |
Endoscopy Division, National Cancer Center Hospital |
| Author |
Yasuo Kakugawa |
Endoscopy Division, National Cancer Center Hospital / Division of Screening Technology and Development, Research Center for Cancer Prevention and Screening, National Cancer Center Hospital |
| Author |
Takahisa Matsuda |
Endoscopy Division, National Cancer Center Hospital |
| Author |
Yutaka Saito |
Endoscopy Division, National Cancer Center Hospital |
| Author |
Hirokazu Taniguchi |
Pathology Division, National Cancer Center Hospital |
| Author |
Ryoji Kushima |
Pathology Division, National Cancer Center Hospital |
| Author |
Kensei Tobinai |
Department of Hematology, National Cancer Center Hospital |
| [ Summary ] |
The endoscopic diagnosis and treatment of colorectal lymphomas are reviewed based on a large series of patients with this disease treated in the National Cancer Center Hospital, Tokyo, Japan. Primary lymphomas account only for 0.4 % of all malignant neoplasms treated at this site. Abdominal pain, weight loss and an abdominal mass are the common presenting symptoms. The common sites of involvement are the ileocaecal region and the rectum. The most frequent histologic type was diffuse large B-cell lymphoma. Mantle cell lymphoma and follicular lymphoma in colorectal lymphomas were more frequently observed than those observed in gastric lymphomas. The tumors were macroscopically classified into Polypoid types, Ulcerative types, MLP (multiple lymphomatous polyposis), Diffuse types and Mixed types were observed with colonoscopies. The majority of macroscopic types were Polypoid types and Ulcerative types. Colorectal lymphomas exhibited endoscopically distinctive features depending on the histological type. Treatment, including surgery, chemotherapy and radiotherapy, should be considered based on the histological type and clinical stage. |