| Theme |
Non-B, Non-C Hepatocellular Carcinoma : The Latest Findings |
| Title |
Hepatocellular Carcinoma in Alcoholic Liver Disease |
| Author |
Yoshinori Horie |
Department of Internal Medicine, International University of Health and Welfare, Sanno Hospital / Division of Gastroenterology & Hepatology, Department of Internal Medicine, School of Medicine, Keio University |
| Author |
Yoshiyuki Yamagishi |
Division of Gastroenterology & Hepatology, Department of Internal Medicine, School of Medicine, Keio University |
| Author |
Hirotoshi Ebinuma |
Division of Gastroenterology & Hepatology, Department of Internal Medicine, School of Medicine, Keio University |
| Author |
Toshifumi Hibi |
Division of Gastroenterology & Hepatology, Department of Internal Medicine, School of Medicine, Keio University |
| [ Summary ] |
In a nationwide survey concerning hepatocellular carcinoma (HCC), alcoholic liver disease (ALD) related-HCC accounted for 7.2 % of all HCC cases, followed by a group with unknown causes of HCC (5.1 %). In HCC without viral hepatitis, the age was lower in the ALD-HCC group. Male gender and the prevalence of LC were higher in the ALD-HCC group. The modest alcohol intake (20-60 g/day) subgroup in unknown HCC cases exhibited the same trends regarding age, gender, body mass index, prevalence of diabetes mellitus (DM), obesity, and liver function as the ALD-HCC group.
Regarding HCC in relation to alcoholic liver cirrhosis (ALC), the prevalence of HCC was 32.3 % in males, and 19.8 % in females. In ALC patients with DM or obesity, or in elderly patients, the prevalence of HCC was higher. Age, obesity and DM appeared to be involved in the progression of HCC in ALC. Imaging procedures are required regularly, especially for elderly habitual drinkers and habitual drinkers with DM or who are obese. |