| Theme |
Carcinogenesis Based on H. pylori-associated Gastritis -- Is Cancer Control Possible by the Eradication ? |
| Title |
Long-term Effect of Helicobacter pylori Eradication on the Development of Metachronous Gastric Cancer after Endoscopic Resection of Early Gastric Cancer |
| Author |
Yuji Maehata |
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University |
| Author |
Shotaro Nakamura |
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University |
| Author |
Takayuki Matsumoto |
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University |
| [ Summary ] |
Metachronous gastric cancers often develop after endoscopic resection of early gastric cancer. A prospective, randomized trial in Japan indicated that H. pylori eradication reduced the incidence of metachronous gastric cancer during a 3-year follow-up. In our recent retrospective study, however, metachronous gastric cancer developed over a long term after H. pylori eradication and the eradication did not significantly reduce the incidence of metachronous gastric cancer. A logistic regression analysis revealed baseline severe mucosal atrophy and a follow-up of more than 5 years to be independent risk factors for the development of metachronous gastric cancer. We thus consider that H. pylori eradication should be performed before the progression of mucosal atrophy to prevent gastric cancer. Careful follow-up endoscopy is warranted over the long term because metachronous gastric cancer can be found a long time after H. pylori eradication. |