| 特集名 | 消化管リンパ腫―最近の知見 | |
|---|---|---|
| 題名 | 胃MALTリンパ腫に対するH. pylori除菌治療 | |
| 発刊年月 | 2012年 12月 | |
| 著者 | 小野 尚子 | 北海道大学病院光学医療診療部 |
| 著者 | 加藤 元嗣 | 北海道大学病院光学医療診療部 |
| 著者 | 浅香 正博 | 北海道大学病院光学医療診療部 |
| 【 要旨 】 | 胃mucosa-associated lymphoid tissue（MALT）リンパ腫の多くはHelicobacter pylori（H. pylori）感染を背景として発症し，H. pylori除菌治療により60〜80％の症例で寛解する．H. pylori陰性例では除菌による寛解率は低いものの，まず除菌治療を試みることが多い． 除菌抵抗性の因子としては，臨床病期，深達度，近位胃，t (11；18)／API2-MALT1転座，H. pylori陰性が挙げられる． 除菌後の長期成績の報告が少なく，再燃率にはばらつきがあるが，胃MALTリンパ腫の生命予後は良好である． |
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| Theme | Gastrointestinal Lymphoma -- Recent Advances in the Diagnosis and Management | |
|---|---|---|
| Title | H. pylori Eradication Therapy for Gastric MALT Lymphoma | |
| Author | Shoko Ono | Division of Endoscopy, Hokkaido University Hospital |
| Author | Mototsugu Kato | Division of Endoscopy, Hokkaido University Hospital |
| Author | Masahiro Asaka | Division of Endoscopy, Hokkaido University Hospital |
| [ Summary ] | Helicobacter pylori (H. pylori) plays a causative role in the development of gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Eradication of H. pylori leads to complete remission of the disease in 60 - 80 % of gastric MALT lymphoma cases. Although eradication therapy is not effective for H. pylori-negative cases, eradication is often recommended as the primary therapy. Predictors of resistance to eradication therapy are an absence of H. pylori, clinical stage, depth of lymphoma invasion, proximal location and t (11 ; 18)/API2-MALT1. Recently, there have been reports concerning long-term follow-ups to determine outcomes after eradication therapy. These reports have stated that the prognosis for gastric MALT lymphoma is excellent after this treatment. |
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