| Theme |
Benign to Low-malignant Pancreatobiliary Lesionst |
| Title |
Mucin-producing Bile Duct Tumors |
| Author |
Yu Takahashi |
Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine |
| Author |
Tomoki Ebata |
Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine |
| Author |
Yukihiro Yokoyama |
Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine |
| Author |
Tsuyoshi Igami |
Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine |
| Author |
Gen Sugawara |
Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine |
| Author |
Masato Nagino |
Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine |
| [ Summary ] |
Mucin-producing bile duct tumors are relatively rare. They secrete macroscopically observed excessive mucin into the biliary system and exhibit unique clinicopathological findings. In addition, these tumors present a more favorable prognosis after curative resection than common bile duct cancer. Radiologic findings of this disease include marked dilatation of intra- and extrahepatic bile ducts and localized cystic dilatation of the intrahepatic bile ducts with papillary projection, as observed with CT scans. Large amorphous filling defects caused by retention of mucin are present in cholangiographic examinations. Histopathologically, the greater part of these tumors consists of papillary carcinomas or well differentiated adenocarcinomas. In addition, they remain localized in the mucosal layer. Moreover, these tumors are often associated with superficial spreading. This disease has been recognized as sharing clinicopathologic features of pancreatic intraductal papillary-mucinous neoplasms (IPMN). Recently, it has been suggested that papillary-type biliary tumors, including mucin producing bile duct tumors, biliary papilloma/papillomatosis, papillary carcinoma of the bile duct, and intraductal growth type cholangiocaricinomas should be lumped together as intraductal papillary neoplasms of the bile duct (IPNB) and that they are counterpart of pancreatic IPMN. |