| Theme |
Diversified Modalities of Liver Metastasis Treatment |
| Title |
Multidisciplinary Therapy with Preoperative Hepatic Arterial Infusion for Liver Metastases from Colorectal Cancer |
| Author |
Takuya Nakai |
Department of Surgery, Kinki University School of Medicine |
| Author |
Kiyotaka Okuno |
Department of Surgery, Kinki University School of Medicine |
| [ Summary ] |
After hepatic arterial immunochemotherapy with 5-fluorouracil (5-FU) and polyethylene glycol-interferon alpha-2a (PEG-IFNα-2a) was performed for treatment of unresectable liver metastasis from colorectal cancer, hepatic resection was performed following tumor shrinkage. Fever was observed as an adverse effect of hepatic arterial chemotherapy in all 17 patients on the day of administration. However, drug cessation was required in only one patient, who developed leucopenia. PR was observed in 11 patients, yielding a response rate of 64.7 %. Liver resection was safely performed on eight patients (47.1 %) including two with histories of chemotherapy. The side effects due to preoperative systemic chemotherapy observed in our patients, were greater than those due to hepatic arterial chemotherapy. In addition, this treatment is effective even for patients who have received chemotherapy. This modality should therefore become an accepted method of providing preoperative chemotherapy. |