| 特集名 | 食道癌の治療戦略 | |
|---|---|---|
| 題名 | FDG-PETによる化学放射線療法の効果予測 | |
| 発刊年月 | 2011年 09月 | |
| 著者 | 石原 立 | 大阪府立成人病センター消化管内科 |
| 著者 | 山本 幸子 | 大阪府立成人病センター消化管内科 |
| 著者 | 竹内 洋司 | 大阪府立成人病センター消化管内科 |
| 著者 | 東野 晃治 | 大阪府立成人病センター消化管内科 |
| 著者 | 上堂 文也 | 大阪府立成人病センター消化管内科 |
| 著者 | 飯石 浩康 | 大阪府立成人病センター消化管内科 |
| 【 要旨 】 | われわれは食道癌に対して導入化学療法を行い，腫瘍の化学療法に対する反応をFDG-PETで早期に判定し，その反応をもとに引き続き行う化学放射線療法の効果を予測するストラテジーを考案した．導入化学療法によるSUVmaxの低下率が＞55％の症例では高率にCR（complete response）となった．未だ症例数は少ないものの，PETで判定した導入化学療法に対する腫瘍の反応は化学放射線療法の効果と強く相関しており，本予測法の有用性が示唆された． | |
| Theme | Current Status of Uprising Strategy for Esophageal Cancer Treatment | |
|---|---|---|
| Title | Predicting Effects of Chemoradiotherapy by Induction Chemotherapy Response Assessed by FDG-PET | |
| Author | Ryu Ishihara | Osaka Medical Center for Cancer and Cardiovascular Diseases |
| Author | Sachiko Yamamoto | Osaka Medical Center for Cancer and Cardiovascular Diseases |
| Author | Yoji Takeuchi | Osaka Medical Center for Cancer and Cardiovascular Diseases |
| Author | Koji Higashino | Osaka Medical Center for Cancer and Cardiovascular Diseases |
| Author | Noriya Uedo | Osaka Medical Center for Cancer and Cardiovascular Diseases |
| Author | Hiroyasu Iishi | Osaka Medical Center for Cancer and Cardiovascular Diseases |
| [ Summary ] | Background：We have developed a treatment protocol for esophageal cancer involving induction chemotherapy followed by chemoradiotherapy. This study aims to determine if it was possible to predict the effects of chemoradiotherapy on the basis of responses to induction chemotherapy, assessed by positron emission tomography (PET). Methods : Sixteen patients with Stage II-IV A esophageal cancer were treated using this protocol from April, 2007 to July, 2010. Chemotherapy involved a fluorouracil and platinum-based combination regimen. All patients received PET scans before, and 12-24 days after the beginning of induction chemotherapy. Associations between the response to induction chemotherapy assessed by PET and the effects of chemoradiotherapy were evaluated. Results：Using a cut-off value of 55 % for SUVmax reduction rate, most cancers with CR and without CR were correctly identified. Conclusions : Response to induction therapy assessed by PET was closely linked with the effects of chemoradiotherapy. |
|