臨牀消化器内科 Vol.25 No.5(4)


特集名 血管の異常をきたす消化管疾患
題名 Gastric antral vascular ectasia(GAVE)の診断と治療
発刊年月 2010年 05月
著者 田辺 聡 北里大学医学部消化器内科
著者 堅田 親利 北里大学医学部消化器内科
著者 佐藤 文 北里大学医学部消化器内科
著者 阿江 太佳子 北里大学医学部消化器内科
著者 石戸 謙次 北里大学医学部消化器内科
著者 小泉 和三郎 北里大学医学部消化器内科
【 要旨 】 胃前庭部毛細血管拡張症(gastric antral vascular ectasia;GAVE)は胃前庭部を中心に血管拡張を認める病態であり,消化管出血の原因の一つである.慢性肝疾患,慢性腎不全などに合併し,貧血を主訴に発見される.内視鏡検査では前庭部を中心に放射状に毛細血管の拡張がみられる.診断に際しては近接観察が重要であり,NBI併用拡大観察の有用性も報告されている.内視鏡治療が有用であり,安全性,有効性の点からAPCによる焼灼治療が推奨される.長期成績では再発例もみられ,定期的な経過観察および慢性肝疾患,慢性腎不全に対する全身管理が重要である.再発例に対しては,追加の内視鏡治療が必要である.
Theme Vascular Disorder of Gastro-intestinal Tract
Title Diagnosis and Treatment for Gastric Antral VascularEctasia (GAVE)
Author Satoshi Tanabe Department of Gastroenterology, Kitasato University School of Medicine
Author Chikatoshi Katada Department of Gastroenterology, Kitasato University School of Medicine
Author Aya Sato Department of Gastroenterology, Kitasato University School of Medicine
Author Takako Ae Department of Gastroenterology, Kitasato University School of Medicine
Author Kenji Ishido Department of Gastroenterology, Kitasato University School of Medicine
Author Wasaburo Koizumi Department of Gastroenterology, Kitasato University School of Medicine
[ Summary ] Gastric antral vascular ectasia (GAVE) refers to the presence of vascular ectasia in the antrum on endoscopic examination. GAVE can cause gastrointestinal bleeding and is often associated with systemic diseases such as chronic liver disease, autoimmune disease, and chronic renal failure presenting with iron deficiency anemia. Endoscopically, GAVE is characterized by a typical pattern of red spots organized in stripes, departing radially from the pylorus (i. e., so-called "watermelon stomach"). Narrow Band Imaging with magnifying endoscope has been reported to be useful for diagnosis. Endoscopic treatment can be used to manage hemorrhage caused by GAVE. Argon plasma coagulation (APC) is effective for the temporary control of hemorrhage and anemia due to GAVE, but recurrence can occur on long-term follow-up. Patients should be examined at regular intervals, and chronic liver disease and chronic renal failure should be carefully managed. Additional endoscopic therapy may be needed to treat recurrence.
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