| Theme |
Precancerous Conditions and Cancer High-risk Lesions in the Colorectum |
| Title |
Insulin Resistance and Colorectal Carcinogenesis |
| Author |
Yutaka Yamaji |
Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo |
| Author |
Yoshihiro Isomura |
Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo |
| Author |
Takafumi Sugimoto |
Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo |
| Author |
Masao Omata |
Yamanashi Prefectural Hospital Organization |
| Author |
Kazuhiko Koike |
Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo |
| [ Summary ] |
Obesity is a risk factor for colorectal neoplasms. An association with visceral fat and metabolic syndrome have also been reported. Obesity and the number of colorectal neoplasms have rapidly increased in Japan in parallel with the adoption of Western lifestyles. Colorectal neoplasms have long been associated with lifestyle. However, recent studies suggest not only are various carcinogenic or anticarcinogenic agents involved but obesity alone may be involved in the primary mechanisms affecting colorectal carcinogenesis. Visceral adiposity accompanying obesity induces insulin resistance, which may be mediated by various adipocytokines. Increased insulin and insulin-like growth factor in insulin resistance status are likely to induce colorectal carcinogenesis. |