| Theme |
Precancerous Conditions and Cancer High-risk Lesions in the Colorectum |
| Title |
Gastrointestinal Polyposes and Malignant Neoplasms |
| Author |
Yuji Maehata |
Medical and Clinical Science, Graduate School of Medical Sciences, Kyushu University |
| Author |
Takayuki Matsumoto |
Medical and Clinical Science, Graduate School of Medical Sciences, Kyushu University |
| Author |
Tomohiko Moriyama |
Medical and Clinical Science, Graduate School of Medical Sciences, Kyushu University |
| Author |
Kazuoki Hizawa |
Medical and Clinical Science, Graduate School of Medical Sciences, Kyushu University |
| Author |
Mitsuo Iida |
Medical and Clinical Science, Graduate School of Medical Sciences, Kyushu University |
| [ Summary ] |
Gastrointestinal polyposes, classified into the categories of adenomatous, hamartomatous, and non-hereditary polyposis have a high risk of becoming cancerous. Adenomatous polyposis is characterized by the development of multiple colorectal adenomas. Most patients develop invasive colorectal cancers if they are not treated at an early stage. Hamartomatous and other polyposes, including juvenile polyposis, Cronkhite-Canada syndrome and hyperplastic polyposis complicate cancers mainly in the gastrointestinal tract. In Peutz-Jeghers syndrome malignant neoplasms occur predominantly in the breast, pancreas, ovaries and uterus, and in Cowden's disease they occur in the breasts and thyroid. Intensive and systemic surveillance is therefore desirable for patients with gastrointestinal polyposes. |