| Theme |
Risk Factors and Prevention of Gastric Cancer |
| Title |
Risk Factors for Gastric Cancer Incidence in General Population : The Hisayama Study |
| Author |
Kentaro Shikata |
Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University / Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University |
| Author |
Yutaka Kiyohara |
Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University |
| Author |
Mitsuo Iida |
Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University |
| [ Summary ] |
Since 1961, an accurate epidemiological study of lifestyle-related diseases has been ongoing in the town of Hisayama, Japan. When the age-adjusted incidence of gastric cancer was compared in three cohorts consisting of Hisayama residents aged 40 years or over established in 1961, 1974, and 1988, the incidence did not change in cohorts consisting of men, though it significanfly declined over time in women. In a follow-up study of the 1988 Hisayama cohort, various lifestyle and environmental factors as well as medical conditions namely, atrophic gastritis, high salt intake, cigarette smoking, hyperglycemia, and low serum cholesterol, along with Helicobacter pylori infection have been revealed to be significant risk factors for the development of gastric cancer. It is considered that these risk factors determine the risk of gastric cancer together, and therefore, managing these risk factors comprehensively is required for early detection and prevention of gastric cancer. |