| [ Summary ] |
Advances in genome technology have revealed human genetic variations, such as single nucleotide polymorphisms and copy number variations. Genome-wide association studies of polygenic disorders are currently in progress. Furthermore, next-generation single molecule sequencing technologies have been used to analyze epigenetic profiles and also may provide personal genome sequencing in coming years. Non-coding RNA, including microRNA, apparently plays crucial regulatory roles in transcription and protein translation. Comprehensive analysis of genetics, epigenetics and transcriptomics will improve our understanding of molecular disease processes. This understanding will then facilitate development of novel therapeutics and the practice of 'stratified medicine' to deliver the most appropriate treatment. |