| Theme |
Role of Endoscopy in the Diagnosis and Treatments of Pancreatic Diseases |
| Title |
Combined Treatment with Immunotherapy and Chemotherapy Using EUS Guided Injections for Inoperable Locally Advanced Pancreatic Cancer |
| Author |
Yoshiki Hirooka |
Department of Endoscopy, Nagoya University Hospital |
| Author |
Akihiro Itoh |
Department of Gastroenterology, Nagoya University Graduate School of Medicine |
| Author |
Hiroki Kawashima |
Department of Gastroenterology, Nagoya University Graduate School of Medicine |
| Author |
Koji Nonogaki |
Department of Gastroenterology, Nagoya University Graduate School of Medicine |
| Author |
Hidemi Goto |
Department of Endoscopy, Nagoya University Hospital / Department of Gastroenterology, Nagoya University Graduate School of Medicine |
| Author |
Kazuo Hara |
Department of Gastroenterology, Aichi Cancer Center |
| [ Summary ] |
Dendritic cell (DC) therapy frequently induces a measurable immune response. However, clinical responses are seen in a minority of patients, presumably due to insufficient expansion of antigen-specific CTLs, which are capable of eradicating tumour cells. The purpose of this trial was to increase the therapeutic efficacy of DC-based vaccinations. We undertook the first clinical trial involving a combination therapy employing gemcitabine (GEM) along with immunotherapy for patients with inoperable locally advanced pancreatic cancer. |