臨牀消化器内科 Vol.23 No.5(10)


特集名 炎症性腸疾患治療のup to date
題名 炎症性腸疾患における新規治療
発刊年月 2008年 05月
著者 蘆田 知史 旭川医科大学内科学講座消化器・血液腫瘍制御内科学分野
著者 高後 裕 旭川医科大学内科学講座消化器・血液腫瘍制御内科学分野
【 要旨 】 炎症性腸疾患 (IBD) は本邦においても患者数が増加し,臨床上大きな問題となっているが,その原因は未だ明らかにされていない部分が多い.しかし,多くの研究結果から新しい治療薬が次々と臨床試験に供され,市販されるに至る時代となった.新規に開発されたサイトカインや細胞表面分子に対する抗体医薬品のいくつかは,IBDに対して優れた治療効果を発揮することが臨床試験で明らかとなった.
Theme Up-to-date Treatment for Inflammatory Bowel Diseases
Title Recently Developed Biologic Therapies for IBD
Author Toshifumi Ashida Third Department of Internal Medicine, Asahikawa Medical College
Author Yutaka Kohgo Third Department of Internal Medicine, Asahikawa Medical College
[ Summary ] The incidence and prevalence of ulcerative colitis (UC) and Crohn's disease (CD), known to as inflammatory bowel diseases (IBD). have greatly increased in Japan. The precise mechanisms underlying the development of IBD are still not known. However, evidence from clinical trials have proven the efficacy of IBD treatments utilizing newly developed, humanized or human monoclonal antibodies for treatment of pro-inflammatory cytokines. This evidence has been compiled in the US and Europe and a small number of these antibodies are now regarded as new biologics and are already in practical use. Nationwide clinical trials of these drugs have begun or will, soon begin in Japan. The representative data concerning clinical trials of new biologics, and other possible therapeutic modalities will be available in the near future.
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