Theme |
A Trend in the Practice of Pancreatitis |
Title |
Autoimmune Pancreatitis and Extra-pancreatic Lesions-the Pathogenesis and Disease Concept |
Author |
Hideaki Hamano |
Department of Gastroenterology, Shinshu University School of Medicine |
Author |
Norikazu Arakura |
Department of Gastroenterology, Shinshu University School of Medicine |
Author |
Mari Takayama |
Department of Gastroenterology, Shinshu University School of Medicine |
Author |
Takeshi Uehara |
Department of Laboratory Medicine, Shinshu University School of Medicine |
Author |
Shigeyuki Kawa |
Center for Health, Safety and Environmental Management, Shinshu University |
Author |
Eiji Tanaka |
Department of Gastroenterology, Shinshu University School of Medicine |
[ Summary ] |
Autoimmune pancreatitis (AIP) is a unique form of chronic pancreatitis characterized by high serum IgG4 concentrations and histological features such as those observed with lymphoplasmacytic sclerosing pancreatitis (LPSP) and abundant IgG4-bearing plasma cell infiltration. AIP has been reported to be associated with a variety of extra-pancreatic lesions including lachrymal and salivary glands, bile duct, pulmonary hilar lymph nodes, retroperitoneal lesions and prostate. Therefore, AIP should be recognized as a systemic inflammatory disease. |