臨牀消化器内科 Vol.23 No.1(15)


特集名 EMR vs. ESD
題名 拡大内視鏡観察による大腸腫瘍の治療法選択 -- 内視鏡的治療と外科的治療の選択を中心に
発刊年月 2008年 01月
著者 二上 敏樹 東京慈恵会医科大学消化器肝臓内科
著者 斎藤 彰一 東京慈恵会医科大学内視鏡科
著者 相原 弘之 東京慈恵会医科大学内視鏡科
著者 荒川 廣志 東京慈恵会医科大学内視鏡科
著者 貝瀬 満 東京慈恵会医科大学内視鏡科
著者 田尻 久雄 東京慈恵会医科大学消化器肝臓内科/東京慈恵会医科大学内視鏡科
著者 池上 雅博 東京慈恵会医科大学病院病理部
【 要旨 】 大腸腫瘍に対する治療法の選択には,1,000 μmを指標とした,SM浸潤度の術前診断が重要と考えられる.通常観察でSM浸潤を疑う所見がなければ内視鏡的治療を,あれば拡大観察におけるpit pattern診断を行う.VN型pitは,外科的治療適応の有用な指標となった.VI型pitについては,表面型腫瘍では,軽度不整pitで内視鏡的治療の,高度不整pitで外科的治療の適応になる傾向がみられた.一方で隆起型腫瘍における粘膜内病変の残存している症例では,深達度診断に困難を生じる場合がみられた,このような病変では,NBI (Narrow Band Imaging) 拡大観察やEUSも併用し付加診断する必要があると考えられた.
Theme Therapeutic Strategy for Early Gastrointestinal Cancers with EMR or ESD
Title Treatment Strategy for Colorectal Tumors Using Magnifying Colonoscopy -- Endoscopic Treatment or Surgical Resection ?
Author Toshiki Nikami Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine
Author Shoichi Saito Department of Endoscopy, The Jikei University School of Medicine
Author Hiroyuki Aihara Department of Endoscopy, The Jikei University School of Medicine
Author Hiroshi Arakawa Department of Endoscopy, The Jikei University School of Medicine
Author Mitsuru Kaise Department of Endoscopy, The Jikei University School of Medicine
Author Hisao Tajiri Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine / Department of Endoscopy, The Jikei University School of Medicine
Author Masahiro Ikegami Department of Pathology, The Jikei University School of Medicine
[ Summary ] Endoscopic diagnosis of whether submucosal invasion is less than 1,000 μm or is deeper, is important to decide on treatment for colorectal tumors. Endoscopic treatment is selected for tumors without conventional colonoscopic findings suggesting submucosal cancer. On the other hand, evaluation of pit pattern by magnifying endoscopy is useful to make diagnosis of tumors with those conventional colonoscopic findings. VN pit pattern was a specific indicater for surgical resection. Treatment of type II a / II c tumors with less irregular VI pit pattern, were usually performed with endoscopic resection. Surgical resection for those tumors with highly irregular VI pit, was usually chosen. It was often difficult to diagnose the depth of submucosal invasion of tumors without cropping out on the surface, as seen in type I p / I sp / I s tumors. In such cases, it was considered that magnifying colonoscopy using Narrow Band Imaging (NBI) and endoscopic ultrasonography (EUS) might be useful.
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