特集名 | 消化器臨床医のための病理学 -- 特殊染色を含めて | |
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題名 | 膵内分泌腫瘍 (膵島細胞腫瘍) の病理診断 -- 概念,悪性度,鑑別診断 | |
発刊年月 | 2007年 09月 | |
著者 | 大池 信之 | 昭和大学医学部第一病理学教室 |
著者 | 諸星 利男 | 昭和大学医学部第一病理学教室 |
【 要旨 】 | 膵内分泌腫瘍は比較的まれな腫瘍で,膵腫瘍全体のうちの1 - 2 %を占めるにすぎない.しかしながら,症候性あるいは機能性腫瘍として特徴的な臨床症状を示し,また,通常の癌腫と比較すると予後が期待できるなど,特異的な腫瘍であるといえる.また,画像診断法の進歩・普及に伴い,従来診断が難しかった無症候性 (非機能性) 腫瘍の診断も可能となり,日常経験される機会が増えている.本稿では,おもに膵内分泌腫瘍の概念,良悪性判定,鑑別診断について述べている.とくに良悪性判定については最新のWHO分類の内容を具体的に紹介し,多少の問題点を踏まえた解説を加えている. |
Theme | Guidebook of Pathology for Gastroenterologists and Hepatologists ; Including Special Stains and Immunohistochemistry | |
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Title | Pathology of Pancreatic Endocrine Tumors Concepts and Criteria for Malignancy, and Differential Diagnoses | |
Author | Nobuyuki Ohike | First Department of Pathology, Showa University School of Medicine |
Author | Toshio Morohoshi | First Department of Pathology, Showa University School of Medicine |
[ Summary ] | Pancreatic endocrine tumors (PETs) are uncommon and represent 1 - 2 % of all pancreatic neoplasms. PETs, however, are specific, because they may be associated with clinical syndromes of functioning tumors and have better prognoses than more common cancers. In addition, the frequency of detection of PETs has increased due to the development and application of more sensitive diagnostic approaches, such as better imaging techniques and more reliable laboratory tests, which are useful even for non-functional tumors. In this article, the concept, definition and criteria for malignancy, as well as differential diagnoses of PETs are described. In particular, the latest WHO classification, including criteria for malignancy are discussed. |