臨牀消化器内科 Vol.21 No.4(1)


特集名 拡大内視鏡の現況と問題点
題名 食道粘膜の拡大観察の基本
発刊年月 2006年 04月
著者 有馬 美和子 埼玉県立がんセンター消化器内科
著者 有馬 秀明 有馬外科胃腸科
著者 多田 正弘 埼玉県立がんセンター消化器内科
【 要旨 】 表在食道病変の拡大内視鏡観察で得られる基本的な微細血管像と病理組織像との関係について検討した.拡大観察で描出される微細血管パターンは大きく四つに分類される.type 1は細く直線的な乳頭内血管が観察されるもので,ほとんどは健常粘膜であり,type 2は血管の伸長や血管径の拡張はあるが,乳頭内血管構造が保たれるもので,炎症性変化が大半を占めた.type 3は乳頭内血管構造の破壊と口径不同を伴う螺旋状や潰れた赤丸状血管がみられ,配列が不揃いなもので,m1・m2癌がほとんどであった.type 4は乳頭構造から逸脱した多重状,不整樹枝状,網状の血管で,m2深部以深浸潤癌にみられる.浸潤部で形成される腫瘍塊は,avascular area (AVA) として認識され,AVAを取り囲むストレッチされたtype 4血管が観察され,AVAの大きさから深達度が鑑別できる.
Theme Current Status of Magnifying Endoscopy
Title Diagnosis of Microvascular Patterns in Superficial Esophageal Lesions, Employing Magnifying Endoscopy
Author Miwako Arima Department of Gastroenterology, Saitama Cancer Center
Author Hideaki Arima Arima Surgical-Gastrointestinal Clinic
Author Masahiro Tada Department of Gastroenterology, Saitama Cancer Center
[ Summary ] We examined whether microvascular patterns seen with magnifying endoscopy could be used to estimate superficial esophageal lesions. Microvascular patterns seen with magnifying endoscopy were classified into four types. Type 1 was characterized by thin, linear capillaries in the subepithelial papilla and was generally seen in normal mucosa. Type 2 was characterized by distended, dilated vessels and the shape of capillaries in the subepithelial papilla was preserved. Type 2 was generally seen in inflammatory lesions. Type 3 was characterized by spiral vessels with an irregular caliber, and crushed vessels with red spots. The arrangement of the vessels was also irregular. Type 3 was generally seen in m1 or m2 cancers. Type 4 was characterized by multi-layered, irregularly branched, reticular vessels with an irregular caliber. Type 4 was generally seen in cancers with deep m2 or deeper invasion. Avascular areas (AVAs) and stretched type 4 vessels were seen in cancers with downward growth. The size of AVAs was closely related to the depth of cancer invasion. The size of AVAs and associated type 4 vessels can be used to assess the extent and depth of tumor invasion. Histopathological features of superficial esophageal cancers can be diagnosed by evaluating microvascular patterns seen with magnifying endoscopy.
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