| Theme |
IPMT ; Intraductal Papillary-Mucinous Tumor |
| Title |
Molecular-Biological Features of Intraductal Papillary-Mucinous Tumors |
| Author |
Noritoshi Kobayashi |
Gastroenterology Division, Yokohama City University Hospital, Yokohama City University Graduate School of Medicine |
| Author |
Kensuke Kubota |
Gastroenterology Division, Yokohama City University Hospital, Yokohama City University Graduate School of Medicine |
| Author |
Atsushi Nakajima |
Gastroenterology Division, Yokohama City University Hospital, Yokohama City University Graduate School of Medicine |
| [ Summary ] |
Intraductal papillary-mucinous tumors (IPMTs) of the pancreas are characterized by slower growth compared with invasive ductal carcinomas of the pancreas (IDCs). However, some invasive IPMTs show a rapid progression and have a poor prognosis, similar to IDCs. The clinical features of IPMTs are sometimes similar to IDCs. The difference between the molecular-biological features of IPMTs and IDCs are very important factors for diagnosis. We will explain some molecular-biological features of IPMTs, in relation to genetic changes, clonality and mucin expression. K-ras codon 12 mutations are often detectable in the early stages of IPMTs. However, this mutation is also frequently seen without any relationship to pathological grade. The expression of p 53 protein or LOH of the p53 gene may be an indicator of the malignancy of IPMTs. These mutation patterns are similar to IDCs. Most IPMTs are polyclonal or oligoclonal in origin and different from IDCs with mucin expression patterns (MUC 1, MUC 2, MUC 5 AC). IPMTs and IDCs are clearly different entities in relation to their clinical and molecular-biological features. |