| Theme |
Non-B, Non-C Hepatitis |
| Title |
Clinical Course of Nonalcoholic Steatohepatitis (NASH) after Treatment of Combined Lifestyle Related Diseases |
| Author |
Eishiro Mizukoshi |
Department of Gastroenterology, Kanazawa University Hospital |
| Author |
Masaaki Kitahara |
Department of Gastroenterology, Kanazawa University Hospital |
| Author |
Tatsuya Yamashita |
Department of Gastroenterology, Kanazawa University Hospital |
| Author |
Kuniaki Arai |
Department of Gastroenterology, Kanazawa University Hospital |
| Author |
Toshinari Takamura |
Department of Gastroenterology, Kanazawa University Hospital |
| Author |
Shuich Kaneko |
Department of Gastroenterology, Kanazawa University Hospital |
| [ Summary ] |
Nonalcoholic steatohepatitis (NASH) has been etiologically associated with lifestyle related diseases, such as obesity, diabetes mellitus or hyperlipidemia. No effective treatment has been demonstrated to alter the natural history of NASH. In the absence of established therapeutic modalities, treatment of NASH is generally directed toward correction of risk factors. In the present study, we treated 35 patients who had lifestyle related diseases and analyzed their effects on natural histories related to NASH. The number of patients responding to treatment for lifestyle related diseases, with aminotransferases and biological markers for hepatic fibrosis has decreased. In the analysis of 10 patients with serial liver biopsies, histological NASH scores also improved or were stablized in the patients studied. The present data suggests that treatment of lifestyle related diseases may be effective in the prevention of progressive NASH diseases. Large, long term prospective studies are necessary to prove the efficacy of treatment of lifestyle related diseases and to establish new treatments for NASH. |