| Theme |
The Latest Frontier of Endoscopy |
| Title |
In Vivo Observation of Living Cancer Cell Using Ultra-High Magnifying Endoscopy |
| Author |
Haruhiro Inoue |
Digestive Disease Center, Showa University Northern Yokohama Hospital |
| Author |
Satoshi Sugaya |
Digestive Disease Center, Showa University Northern Yokohama Hospital |
| Author |
Makoto Kaga |
Digestive Disease Center, Showa University Northern Yokohama Hospital |
| Author |
Keita Sasajima |
Digestive Disease Center, Showa University Northern Yokohama Hospital |
| Author |
Yoshitaka Sato |
Digestive Disease Center, Showa University Northern Yokohama Hospital |
| Author |
Noriko Odaka |
Digestive Disease Center, Showa University Northern Yokohama Hospital |
| Author |
Hitoshi Satodate |
Digestive Disease Center, Showa University Northern Yokohama Hospital |
| Author |
Shin-ei Kudo |
Digestive Disease Center, Showa University Northern Yokohama Hospital |
| Author |
Akira Shiokawa |
Division of Pathology, Showa University Northern Yokohama Hospital |
| [ Summary ] |
Recent advancements in endoscopic imaging technology enable the visualization of early stage cancer or precursors to it. Chromoendoscopy, magnifying endoscopy or combinations of these two play important roles in making small, unclear lesions recognizable. Two types of ultrahigh magnifying endoscopes have also been developed which have more than a 1,000 x magnifying power at their maximum. Living cancer cells and normal cells in the gastrointestinal tract were successfully observed in high quality images. “Endo-Microscopy” is an application of laser-scanning confocal technology. “Endo-Cytoscopy” is one application of contact light based microscopic technology. By utilizing these imaging technologies living cells in both the normal mucosa and cancerous tissue were clearly demonstrated in the gastrointestinal tract. In particular, cells and nuclei were clearly demonstrated with high quality images, similar to those produced by conventional cytology or histology of biopsy specimens. |