臨牀消化器内科 Vol.20 No.9(5-2)


特集名 GIST (gastrointestinal stromal tumor)
題名 GISTの内視鏡・超音波内視鏡診断 (2) 小腸・大腸
発刊年月 2005年 08月
著者 山田 雅弘 名古屋大学大学院医学系研究科病態修復内科
著者 丹羽 康正 名古屋大学大学院医学系研究科病態修復内科
著者 大宮 直木 名古屋大学大学院医学系研究科病態修復内科
著者 後藤 秀実 名古屋大学大学院医学系研究科病態修復内科
【 要旨 】 小腸・大腸GISTは比較的まれな疾患である.内視鏡所見は胃GISTと同様で,腫瘍は正常粘膜に被覆された粘膜下腫瘍の形態をなし,随伴所見として,びらんや潰瘍を伴う.超音波内視鏡 (EUS) は粘膜下腫瘍に対してその診断的有用性が報告されている.GISTのEUS所見は,消化管壁の第4層と連続した低エコー腫瘤で,しばしば境界の不整や内部無エコー領域を伴う.しかし,EUS診断に疑問が生じる症例も時に見受けられる.このような症例では,超音波内視鏡下穿刺吸引組織診断 (EUS-FNA) が病理診断に有用である.今後は,ダブルバルーン内視鏡やカプセル内視鏡の普及に伴い,術前診断可能な小腸GIST症例が増加すると思われる..
Theme GIST (gastrointestinal stromal tumor)
Title Endoscopic Diagnosis of GIST : Small and Large Intestine
Author Masahiro Yamada Division of Therapeutic Therapy, Department of Internal Medicine, Nagoya Graduate School of Medicine
Author Yasumasa Niwa Division of Therapeutic Therapy, Department of Internal Medicine, Nagoya Graduate School of Medicine
Author Naoki Ohmiya Division of Therapeutic Therapy, Department of Internal Medicine, Nagoya Graduate School of Medicine
Author Hidemi Goto Division of Therapeutic Therapy, Department of Internal Medicine, Nagoya Graduate School of Medicine
[ Summary ] Small intestinal and large intestinal GISTs are comparatively rare diseases. Endoscopic findings of these GISTs are the same as those of gastric GISTs. The tumor is covered by normal mucosa and has the configuration of submucosal tumors with bridging folds and, also the accompanying findings of erosion and ulcers. EUS has recently been reported to be useful in the diagnosis of submucosal tumors. In EUS findings, GIST originates in the fourth sonographic layer of the GI tract wall and is often accompanied with irregular borders or cystic spaces. However, there are some cases in which the EUS diagnosis is questionable. In such cases, ensdoscopic ultrasound guided fine needle aspiration (EUS-FNA) is a useful technique for histological diagnosis. With the increased use of double balloon enteroscopy and capsular enteroscopy, it seems that more small intestinal GISTs will be diagnosed preoperatively in the future.
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