| [ Summary ] |
Nonalcoholic steatohepatitis (NASH) is closely related with diseases such as obesity, diabetes, hypertension and atherosclerosis, and is considered to be a hepatic manifestation of metabolic syndromes. These metabolic disorders, including NASH, are associated with insulin resistance, and abnormalities in glucose and lipid metabolisms. However, the mechanisms involved are complex. In this review, we discuss the mechanisms of fatty liver formation and especially those associated with the progression to NASH. We especially highlighted the role of oxidative stress caused by many factors such as reactive oxygen species, lipid peroxidation products, cytokines, adipocytokines, mitochondrial dysfunction, and endotoxins. Further exploration should be done from many aspects to elucidate the multifactorial mechanisms involved in NASH. |