| 特集名 | Helicobacter pylori update | |
|---|---|---|
| 題名 | H. pylori除菌後に起こる諸問題 | |
| 発刊年月 | 2005年 01月 | |
| 著者 | 鎌田 智有 | 川崎医科大学内科学食道・胃腸科 |
| 著者 | 杉生 訓昭 | 川崎医科大学内科学食道・胃腸科 |
| 著者 | 村中 亜紀 | 川崎医科大学内科学食道・胃腸科 |
| 著者 | 楠 裕明 | 川崎医科大学内科学食道・胃腸科 |
| 著者 | 畠 二郎 | 川崎医科大学検査診断学 |
| 著者 | 春間 賢 | 川崎医科大学内科学食道・胃腸科 |
| 【 要旨 】 | Helicobacter pylori (H. pylori) 除菌後に発生する問題として，逆流性食道炎，クラリス口マイシン耐性菌の増加，除菌後に発見される胃癌および肥満・高脂血症の発生などが現在のところ指摘されている． 胃体部胃炎および食道裂孔ヘルニアを認める症例は除菌後に逆流性食道炎を発生しやすいため，除菌前に患者への十分なinformed consentが必要である．しかしながら，除菌後に発生する逆流性食道炎の多くが軽症例であること，長期経過も良好であるため臨床的な問題は少ないと考えられる．今後，食道腺癌の発生については長期に経過観察する必要がある． |
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| Theme | Helicobacter pylori update | |
|---|---|---|
| Title | Various Problems After Eradication of Helicobacter pylori | |
| Author | Tomoari Kamada | Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School |
| Author | Kuniaki Sugiu | Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School |
| Author | Aki Muranaka | Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School |
| Author | Hiroaki Kusunoki | Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School |
| Author | Jiro Hata | Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School |
| Author | Ken Haruma | Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School |
| [ Summary ] | Recently, various problems after eradication of Helicobacter pylori (H. pylori) have been reported, such as the development of reflux esophagitis, increases in clarithromycin resistance to H. pylori, and the occurrence of gastric cancer and obesity. The presence of hiatal hernias and corpus gastritis are closely related to the development of reflux esophagitis after eradication of H. pylori. Therefore, full informed consent by patients is needed before eradication of H. pylori. Because it is rare for reflux esophagitis, which develops after eradication of H. pylori, to become severe and cause longterm reflux symptoms, it rarely becomes a longterm clinical problem among patients who complete therapy successfully. Further study needs to be done on the development of Barrett's mucosa, which may be a cause of esophageal adenocarcinoma. |
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