| Theme |
Risk Factors for Gastric Carcinogenesis |
| Title |
H.pylori Infection and Gastric Cancer: Hypoacidity and Carcinogenesis |
| Author |
Akiko Shiotani |
Health Administration Center, Wakayama University |
| Author |
Mitsutaka Kumamoto |
Aishinkai Nakae Hospital |
| Author |
Hiroyasu Iishi |
Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases |
| [ Summary ] |
The intestinal type of gastric cancer is preceded by chronic inflammation and atrophic gastritis, which in turn result in impairment of defense mechanisms and additionally induce hypergastrinemia, vitamin C deficiency, excessive reactive oxygen metabolites (ROMs), increase in N-nitroso compounds (NOCs), and epithelial cell proliferation in the stomach. A particular sequence of inflammatory events induced by H.pylori infection probably acts as an initiator of gastric cancer; on the other hand, hypoacidity may act as a key determinant for the alterations and mutations of apoptosis regulating genes, resulting in a loss of balance between apoptosis and cell proliferation. |