| Theme |
Diet as Etiologic Factors and Therapeutic Tools in Digestive Diseases |
| Title |
Dietary Habits and Microbial Infection as Risk Factors for Gastric Carcinogenesis |
| Author |
Mototsugu Kato |
Division of Endoscopy, Hokkaido University Hospital |
| Author |
Souichi Nakagawa |
Division of Endoscopy, Hokkaido University Hospital |
| Author |
Yuichi Shimizu |
Division of Endoscopy, Hokkaido University Hospital |
| Author |
Manabu Nakagawa |
Department of Gastroenterology, Hokkaido University Graduate School of Medicine |
| Author |
Junji Yamamoto |
Department of Gastroenterology, Hokkaido University Graduate School of Medicine |
| Author |
Masahiro Asaka |
Department of Gastroenterology, Hokkaido University Graduate School of Medicine |
| [ Summary ] |
Since almost all gastric cancers occur in H. pylori infected gastric mucosa, H. pylori infection is recognized as playing an important role in the development of gastric cancer. However, in epidemiological studies many factors are considered to be associated with the risk of gastric cancer. Risk factors for gastric carcinogenesis include microbial infections such as H. pylori and Epstein-Barr virus. Dietary habits, such as high salt intake, high intake of starch, chili pepper, smoking, alcohol, and low intake of vegetables and fruits are reported to be closely related to gastric cancer. Eradication treatment of H. pylori infection has a potential to decrease the incidence of gastric cancer, as seen in the interventional results in experimental studies using animal models and prospective clinical trials. H. pylori eradication is concluded to be a candidate for the chemoprevention of gastric cancer. |