臨牀消化器内科 Vol.18 No.3(6)


特集名 早期大腸癌 -- 最近の話題
題名 拡大内視鏡を用いた大腸腫瘍性病変のpit pattern診断
発刊年月 2003年 03月
著者 河野 弘志 久留米大学医学部第2内科
著者 鶴田 修 久留米大学医学部第2内科
著者 辻 雄一郎 久留米大学医学部第2内科
著者 唐原 健 久留米大学医学部第2内科
著者 吉森 建一 久留米大学医学部第2内科
著者 佐田 通夫 久留米大学医学部第2内科
著者 豊永 純 久留米大学医学部消化器病センター
著者 有馬 信之 久留米大学医学部第2病理
【 要旨 】 拡大内視鏡を用いたpit pattern診断で大腸病変の質,深達度診断が可能である.質診断は腫瘍・非腫瘍,腺腫・癌の鑑別が可能で,腺腫・癌はV型pitの有無により約80%診断できる.これは通常内視鏡診断能より優れており,大腸腫瘍性病変質診断への有用性が示唆される.深達度診断は輪郭不明瞭なVIおよびVN型pitの有無によりm~sm1癌とsm2-3癌を約80%鑑別できるが,他検査法による診断能と大差ない.このため深達度診断には必須ではなく,補助的な検査法と考えられる.病理組織学的にはV型pitは構造異型を反映し,とくに輪郭不明瞭なVIおよびVN型pitはdesmoplastic reactionや被覆上皮の変性・脱落と関連しているものと考えられた.
Theme Early Colorectal Cancer -- Recent Topics
Title Effectiveness of Magnifying Endoscopy in Diagnosing Colorectal Lesions
Author Hiroshi Kawano Department of Medicine II, Kurume University School of Medicine
Author Osamu Tsuruta Department of Medicine II, Kurume University School of Medicine
Author Yuichiro Tsuji Department of Medicine II, Kurume University School of Medicine
Author Takeshi Tobaru Department of Medicine II, Kurume University School of Medicine
Author Kenichi Yoshimori Department of Medicine II, Kurume University School of Medicine
Author Michio Sata Department of Medicine II, Kurume University School of Medicine
Author Atsushi Toyonaga Division of Gastroenterology and Endoscopy, Kurume University School of Medicine
Author Nobuyuki Arima Department of Pathology, Kurume University School of Medicine
[ Summary ] Magnifying colonoscopy has received attention as a useful clinical diagnostic modality for colorectal lesions. We evaluated the relationship between pit patterns and histological findings from magnifying colonoscopy. Lesions with type I or II pit patterns are not tumorous, whereas lesions with type IIIs, IIIL, IV or V pit patterns are tumorous. The incidence of cancer is 80% in type V lesions. For diagnosing the invasion depth of colorectal cancer, we created subclassifications of the type V pit pattern; VI with clear outlines, VI with unclear outlines, and VN. The incidence of sm2-3 cancer is 90% in type VN lesions, 70% in type VI with unclear outlines, 30% in VI with clear outlines and 0% in other than type V. Therefore, magnifying colonoscopic examination, using crystal violet staining, proved to be useful for diagnosing colorectal cancer and diagnosing invasive colorectal cancers. However, this method for is not always necessary when diagnosing invasive colorectal cancer. We can diagnose sm2-3 cancer through conventional colonoscopy, and when we can not diagnose sm2-3 cancer through conventional colonoscopy, we should use magnifying colonoscopy.
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