臨牀消化器内科 Vol.18 No.2(4)


特集名 胃癌治療ガイドラインをめぐる諸問題
題名 早期胃癌に対する内視鏡的粘膜切除後のフォローアップと再発の治療
発刊年月 2003年 02月
著者 永尾 重昭 防衛医科大学校第2内科
著者 田島 一美 防衛医科大学校第2内科
著者 松崎 宏治 防衛医科大学校第2内科
著者 宮崎 純一 防衛医科大学校第2内科
著者 北川 敬丈 防衛医科大学校第2内科
著者 川口 淳 防衛医科大学校第2内科
【 要旨 】 リンパ節転移のない早期胃癌に対する内視鏡的粘膜切除術(EMR)は,その術後のQOLの飛躍的な向上を得ることができ,また,高齢化社会に入り,手術不能例や手術高危険例では,癌の根治性からみても,きわめて優れた治療法である.EMRは,根治が必要不可欠な絶対条件であるが,不完全切除,完全切除各々の状況を,EMRの方法論からみて,どのように臨床的に取り扱い,治療後どのように経過観察するか,再発が認められた場合,どのように治療するか,現時点での問題点,現況を文献的考察も加え,将来展望をも含め概説した.
Theme Significance, Problems, and Future Prospect of the Gastric Cancer Treatment Guideline
Title Follow-up Method for Endoscopic-Mucosal Resected Early Gastric Cancer and Additional Treatment for Residual and Locally Recurrent Gastric Cancer Treated with Endoscopic Mucosal Resection
Author Shigeaki Nagao 2nd Internal Medicine, National Defence Medical College
Author Hitomi Tajima 2nd Internal Medicine, National Defence Medical College
Author Kouji Matsuzaki 2nd Internal Medicine, National Defence Medical College
Author Junichi Miyazaki 2nd Internal Medicine, National Defence Medical College
Author Yoshitake Kitagawa 2nd Internal Medicine, National Defence Medical College
Author Atsushi Kawaguchi 2nd Internal Medicine, National Defence Medical College
[ Summary ] At this time, endoscopic treatment for early gastric cancer is expected to provide an absolute cure when lesions are limited to the intramucosal type and not accompanied by lymph node or other organ metastases. This method also provides better provides for the postoperative period with elderly patients than conventional surgical procedures. This is also true for patients with other surgical complications. Endoscopic mucosal resection provides the best cure rate for these lesions. However, when there has been incomplete resection, methods must de developed for futher treament. We discuss additional treatment of residual or recrrent cancer should be employed. If the edge of the incision is positive for cancer, fractionated, resection should be employed through repeated endoscopic mucosal resection to achieve complete resection. If submucosal cancer is found through endoscopic mucosal resection, careful observation, without additional treatment is possible as long as the vertical margin is free of cancer, in the lymphatic ducts and there is no vessel infiltration.
Semiconductor laser irradiation and additional surgery should be considered in these cases.
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