臨牀消化器内科 Vol.17 No.8(5-2)


特集名 内視鏡の偶発症とその対策
題名 EMRによる穿孔と対策 (2) 胃
発刊年月 2002年 07月
著者 赤松 泰次 信州大学附属病院光学医療診療部
著者 中村 直 信州大学附属病院医学部第二内科
著者 松澤 正浩 信州大学附属病院光学医療診療部
著者 望月 太郎 信州大学附属病院医学部第二内科
著者 進士 明宏 信州大学附属病院医学部第二内科
著者 清澤 研道 信州大学附属病院医学部第二内科
【 要旨 】 内視鏡的粘膜切除術(EMR)による胃穿孔6例について検討した.穿孔の原因は,strip biopsy法の4例中3例は固有筋層を巻き込んでスネアリングしたために生じ,予防には局注によって病変と固有筋層を十分に剥離する必要がある.一方,ITナイフを用いたEMRや内視鏡的核出術による穿孔は手技の未熟が原因であった.病変部位は6例中5例がU領域で,その理由として他の部位に比べて胃壁の厚さが薄いことが考えられた.6例中3例は保存的治療で改善したが,止血用クリップを用いて内視鏡的穿孔部閉鎖術を行ったほうが症状が軽く,入院期間も短い傾向がみられた.残りの3例中2例は穿孔した時点で病変が残存していたため,穿孔部を含めて外科的局所切除術を行った.EMRによる胃穿孔は多くの場合,適切に対処すれば保存的治療によって治癒しうるが,慎重に経過観察する必要がある.止血用クリップによる内視鏡的穿孔部閉鎖術は,EMRによる穿孔の治療に有用である.
Theme Complications and their Managements for Gastrointestinal Endoscopy
Title Gastric Iatrogenic Perforation and its Management in Endoscopic Mucosal Resection
Author Taiji Akamatsu Departmeut of Endoscopy, Shinshu University Hospital
Author Naoshi Nakamura The Second Department of Internal Medicine, Shinshu University School of Medicine
Author TMasahiro Matsuzawa Departmeut of Endoscopy, Shinshu University Hospital
Author Taro Mochizuki The Second Department of Internal Medicine, Shinshu University School of Medicine
Author Akihiro Shinji The Second Department of Internal Medicine, Shinshu University School of Medicine
Author Kendo Kiyosawa The Second Department of Internal Medicine, Shinshu University School of Medicine
[ Summary ] Six cases of gastric iatrogenic perforation in endoscopic mucosal resection (EMR) were studied. Gastric perforations were caused by ensnarement of the proper muscular layer in 3 out of 4 cases that were complicated by strip biopsy procedures. It is important to inject adequate quantities of physiological saline between the lesion and the proper muscular layer to prevent gastric perforations. On the other hand, gastric perforations during EMR, using an IT knife and endoscopic scraping enucleation, occurred because of technical errors. The lesions, in all cases except one, were in the U region. The gastric wall in the U regionis thinner compared with that in other regions, therefore, EMR in the U region should be performed more carefully. Three out of 6 cases were treated with conservative therapies, such as inserting a nasogastric tube, fasting, and giving antibiotics as well as gastric acid suppressors intravenously. All three cases were cured. Endoscopic repair, using a clipping device, seemed to reduce the number of complaints and the period of admission. Two of the remaining 3 cases were performed using surgical treatment with local gastric resection because of residue from the lesion. Many gastric iatrogenic perforations are thought to be cured by using appropriate, conservative therapy, but careful follow up is necessary during conservative therapy. Endoscopic repair, using a clipping device is useful to treat for iatrogenic perforation in EMR.
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