| Theme |
Recent Advances in Gastrointestinal Functio Tests |
| Title |
Clinical Trial for Measurement of Gastric Emptying Rates by Using Carbon Labeled Compound |
| Author |
Izumi Ishizuka |
Department of Gastroenterology, Shiga University of Medical Science |
| Author |
Yorihiro Nishiyama |
Department of Gastroenterology, Shiga University of Medical Science |
| Author |
Shigeki Koyama |
Department of Gastroenterology, Shiga University of Medical Science |
| Author |
Tadao Bamba |
Vice President, Shiga University of Medical Science |
| [ Summary ] |
In the present study, we measured gastric emptying rates, using a carbon labeled compound, the 13C-acetate breath test, and evaluated its clinical efficacy as a novel non-invasive method to evaluate gastrointestinal motility compared to the conventional radioisotope (RI) method. Ghoos et al. made the first report in 1988 that a breath test, using a carbon labeled compound might be a useful method for measuring gastric emptying rates. We have two kinds of test meals in the study, hotcakes as a solid enteral nutrient, RacolTM as a liquid. We statistically assessed the residual rate of 13C-acetate in the stomach when using a solid test meal and the half emptying time (T1/2) when using liquid test meals as compared with those of the RI method. The correlation coefficient of the residual rate at 150 minutes after solid intake was 0.9023 and that of T1/2, when liquids were taken, was 0.8377. Results shown in the present study indicate that the 13C-acetate breath test, using enteral nutrients may be the best candidate for measurement of gastric emptying rates with the conventional RI method. However, there are several problems to be solved for popularization of this method, including standardization of test meals and establishment of analytical methods and factors. Repetition of clinical trials using established test methods will be needed in the future. |