| Theme |
Pepsinogen -- Basic, Clinical Implications, and Epidemiology |
| Title |
Development and Differentiation of Pepsinogens |
| Author |
Chie Furihata |
Biology, College of Science and Engineering, Aoyama Gakuin University |
| [ Summary ] |
Pepsinogen (Pg)-producing cells in rat and mouse stomach fundic and pyloric mucosae are summarized. Pg-producing cells first appear in ICR mouse stomach mucosa on day 16 of gestation. These cells appear 2 to 3 days later in Wistar rat stomach mucosa. Pg is ozymes are produced in so-called muco-peptic cells (primitive cells of mucous neck cells and chief cells) until postnatal day 14-17 in the fundic mucosa. During postnatal days 17-30 the fundic mucosa dramatically matures into the adult fundic mucosa. Pg is ozymes are produced in chief cells and mucous neck cells in the adult fundic mucosa. Pg content in the fundic mucosa increases 5-fold and assumes the is ozyme pattern of adult mucosa. Glucocorticoid hormone controls the fundic mucosal maturation. Mucous neck cells are suggested to be intermediate cells in the differentiation to chief cells. Pg isozymes are produced in pyloric gland cells in the pyloric mucosa. Pg production in fetus pyloric mucosa was not studied. Production of Pg isozymes is detected at least on postnatal day 1. Pg isozyme pattern, content of Pg in the pyloric mucosa and morphology of pyloric gland cells observed by electron microscopy are the same as in adult pyloric mucosa. |