| Theme |
Serve Acute Pancreatitis -- Prediction of Deterioration and Therapeutic Strategy |
| Title |
Strategy for Severe Acute Pancreatitis -- Continuous Regional Arterial Infusion of Protease Inhibitors and Antibiotics in the Early Phase of Severe Acute Pancreatitis |
| Author |
Kazunori Takeda |
First Department of Surgery, Tohoku University, School of Medicine |
| Author |
Kazuhiko Shibuya |
First Department of Surgery, Tohoku University, School of Medicine |
| Author |
Makoto Sunamura |
First Department of Surgery, Tohoku University, School of Medicine |
| Author |
Seiki Matsuno |
First Department of Surgery, Tohoku University, School of Medicine |
| [ Summary ] |
Severe acute pancreatitis is defined as a systemic inflammatory disease with infected necrosis, DIC and multiple organ failure. The magnitude of the systemic response depends upon the extent of pancreatic necrosis and extrapancreatic extention of the inflammation. Continuous regional arterial infusion (CRAI) of protease inhibitor and antibiotic is a new pharmacological treatment which inhibit the local events of the pancreas. The mortality rate in patients with acute necrotizing pancreatitis treated by CRAI therapy within 48 hrs after the onset was only 4.6%. CRAI therapy and intensive care should be mandatory to reduce the mortality rate in patients with acute necrotizing pancreatitis. |