| Theme |
For the Effective Eradication of Helicobactor pylori |
| Title |
Changes in Pathogenesis after Eradication of Helicobacter pylori |
| Author |
Naomi Uemura |
Department of Gastroenterology, Kure Kyosai Hospital |
| Author |
Shiro Okamoto |
Department of Gastroenterology, Kure Kyosai Hospital |
| Author |
Soichiro Yamamoto |
Department of Gastroenterology, Kure Kyosai Hospital |
| Author |
Nobutoshi Matsumura |
Department of Gastroenterology, Kure Kyosai Hospital |
| [ Summary ] |
Eradication therapy changes the microenvironment of the stomach, such as gastric acid secretion, histological findings and endoscopic findings. Eradication has been known to improve gastric acid secretion in atrophic gastritis cases. The most evident change seen with eradication is remission of histological gastritis, particularly inflammatory cell infiltration. Hyperplasia of the crypt epithelium, associated with inflammatory cell infiltration and interstitial edema are observed in H.pylori infected gastric mucosa. This change is particularly noted in the greater curvature of the gastric body. In parallel with improvements in hyperplasia of crypt epithelium through eradication, the endoscopic appearance is improved after treatment to eradicate H.pylori. The effect of eradication on the incidence of GERD or reflux esophagitis is now a major focus of attention. The pathogenesis of reflux esophagitis developing after eradication of H.pylori may be associated with the increase in gastric acid secretion. Barrett's esophagus and adenocarcinoma of the esophagus is now a big concern in the U.S. as a consequence of the increased prevalence of GERD ; however, it is not yet evident in Japan. While doing careful examinations around of E-G-junction, we should pay attention to these patients' condition after eradication. |