| Theme |
Portal Hypertension |
| Title |
Portal Hypertensive Gastropathy |
| Author |
Atsushi Toyonaga |
The Second Department of Medicine, Kurume University School of Medicine |
| Author |
Tadashi Iwao |
Iwao Hospital |
| Author |
Kazuhiko Oho |
The Second Department of Medicine, Kurume University School of Medicine |
| Author |
Masahiro Sato |
The Second Department of Medicine, Kurume University School of Medicine |
| Author |
Yasunao Miyamoto |
The Second Department of Medicine, Kurume University School of Medicine |
| Author |
Masashi Kumamoto |
The Second Department of Medicine, Kurume University School of Medicine |
| Author |
Kenji Sakai |
The Second Department of Medicine, Kurume University School of Medicine |
| Author |
Michio Sata |
The Second Department of Medicine, Kurume University School of Medicine |
| [ Summary ] |
Portal-hypertensive gastropathy (PHG), which is characterized by mucosal and submucosal vascular dilatation without inflammation, indicates non-variceal bleeding in patients with cirrhosis. Portal pressure and some humoral factors may play important roles in this pathogenesis. Gastric acid secretory activity is normal or reduced in these cases. In regard to gastric mucosal hemodynamics, it is not known whether "overflow" (i.e., active congestion) or "stasis" (i.e., passive congestion) causes gastric mucosal hyperemia. Treatments, such as pharmacological (e.g., propranolol), surgical (e.g., portosystemic shunt), and radiological (e.g., transjugular intrahepatic portosystemic shunts) procedures may be useful in preventing bleeding from PHG. |