| Theme |
Laser Endoscopy in Theory and Practice --Perspective of GI Endoscopy in the 21st Century |
| Title |
The Mechanisms of Tumor-localizing Capacity of Porphyrins and Their Application for Tumor Diagnosis and Treatment |
| Author |
Susumu Nakajima |
Division of Surgical Operation, Asahikawa Medical College |
| [ Summary ] |
Important factors associated with tumor tissue affinity to porphyrins were explained in relationship to their strong affinity for lipo-proteins and active endocytosis in cancer cells associated with enhancement of LDL and transferrin receptor activities. Recently, specifically connected glycoproteins such as hemopexin have been noted as carriers of porphyrin. A second generation photosensitizer ATX-S1O (Na) which has a strong photo dynamic treatment effect and rapid clearance from normal tissue is expected as a new tumor fluorescnece diagnostic tool, along with the widely clinical application for PDT. |