| [ Summary ] |
These decades, there are many reports about chemoprevention for colorectal cancer, adenomas by various NSAIDs use. In animal models of colorectal carcinogenesis, the effects and potential mechanism of NSAIDs for prevention of colon cancerand regression of colon adenomas are analized.In epidemiclogic studies NSAIDs use significantly decreased relative risk of colorectal cancer(0.7). In clinical trials, regular intake of sulindac or regular use of indomethacin suppository regressed rectal adenomas in FAP patients after subtotal colectomy.There was no reduction of cancer risk for discontinuated use. NSAIDs may cause severe gastrointestinal complications, associated with inhibition of COX-1 enzyme. New class of NSAIDSthat is highly selective for inhibition of the COX-2 enzyme, and that lacks of inhibition of COX-1, is necessary forwidespread cancer prevention. |