| [ Summary ] |
This paper discussed the clinical problems of NSAID-associa-ted ulcers. Their rate of prevalence is suspected to be l0% to 20% in NSAID users. NSAID is an important factor for ulcer management. From the comparison of the report of Japan Rheu-matic Association to the number of ulcer cases admitted to the authors' hospital, we suggested that there are two typi-cal types of NSAID-associated ulcers, that is, those from ch-ronic injuries due to long-term administration and those from acute injuries occuring within a short period of the drug-use. The former injuries are multiple erosions or small ulse-rsin the antrum and occur due to a decrease of mucosal pro-staglandin by systemic delivery of absorbed NSAID from the intestine, and are relieved by prostaglandin administration but in the latter case injuries are large and deep ulcers inthe body and are associated with the role of gaastric acid in gastric absorption of NSAID, and are effectively treated with acid suppressants. |