| 特集名 | C型肝炎ウイルスの肝外症状 | |
|---|---|---|
| 題名 | C型慢性肝炎とクリオグロブリン血症 | |
| 発刊年月 | 1999年 03月 | |
| 著者 | 各務 伸一 | 愛知医科大学第一内科 |
| 【 要旨 】 | 最近，C型肝炎ウイルス(HCV)感染によるクリオグロブリン(CG)血症は，C型肝炎の病態に密接に関連することが，次々に報告されているが，本邦における報告はまだ少ない．筆者らの検討では，CGはC型慢性肝疾患患者の37%に検出されたが，1例を除き，すべてポリクローナルな免疫グロブリンが成分であり，欧米に比べ頻度，構成とも残なっていた．CGは血清CH50低値と免疫複合体高値を示す肝障害進展例により多く検出されたが，血管炎などのいわゆる肝外病変は，約17%の患者にのみ認め，欧米に比し低頻度であった．このように，日本と欧米でのCGの特徴像に差を認めた． | |
| Theme | Extrahepatic Manifestation in HCV Infection | |
|---|---|---|
| Title | Chronic Hepatitis C and Cryoglobulinemia | |
| Author | Shinichi Kakumu | First Department of Internal Medicine, Aichi Medecal University |
| [ Summary ] | The hepatitis C virus (HCV)-associated mixed cryoglobulins (CG) appears to often be detected in hepatitis C related chronic liver disease. However, the association of the two phenomenon among Japanese patients still remains uncertain. CG were detected in 37% of 65patients with type C chronic liver disease. The rate of prevalence rate appeared to be low compared with those reported in Western countries. Patients with CG had lower serum CH50 activity and higher immune complex levels than those without CG. CG consisted of polyclonal immunoglobulins in all but one case. In studies from Western countries, CG contained polyclonal and monoclonal Igs in half of the patients CG were more frequently observed in cirrhotic patients and in those with a longer duration of disease CG-related clinical signs such as vasculitis occurred in only four cases ; this rate also was low in comparison with those seen in Western studies. HCV-RNA and anti-HCV antibodies were detected in all cryoprecipitates tested. In conclusion, the characteristics of CG appeared to differ between Japanese and Western people infected with HCV. |
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