臨牀消化器内科 Vol.14 No.12(2-1)


特集名 薬物治療をめぐるControversy --上部消化管
題名 Peptic Ulcer治療の第一選択は (1) PPI
発刊年月 1999年 11月
著者 井上 正規 広島大学医学部附属病院総合診療部
【 要旨 】 消化性潰瘍の内科的治療として,プロトンポンプインヒビター(PPI)は,H2-ブロッカーに比しはるかに強力な酸分泌抑制作用を有することより,疼痛など自覚症状を速やかに消失させること,潰瘍の早期治癒など多くの点で優れた薬剤であり,ほぼ理想的な第一選択薬として期待される.今後の潰瘍治療学はH2-ブロッカーのOTC(over the counter drug)への移行ならびにH.pylori除菌治療の保険適用と相侯って,消化性潰瘍の治療戦略は大きく変貌していくであろう.
Theme Controversies in the Drug Therapy of Upper Gastrointestinal Tract Disorders
Title Is Treatment of Peptic Ulcer Disease with Proton Pump Inhibitors Gold Standard?
Author Masaki Inoue Department of General Medicine, Hiroshima University School of Medicine
[ Summary ] Proton pump inhibitors have many advantages in the treatment of peptic ulcers, since they have a much more potent inhibitory effect on gastric acid secretion than H2 receptor antagonists, resulting in the prompt disappearance of subjective symptoms such as pain, and resulting in quick healing of ulcers.
They are expected to become an ideal drugs of first choice in the treatment of peptic ulcers. In the future, major changes should take place in therapeutic strategies for peptic ulcers with the switch of H2 receptor antagonists to OTC(over the counter) status, and the expansion of therapy for eradication of Helicobacter pylori covered by health insurance.
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