| [ Summary ] |
Chronic B type hepatitis is a typical chronic liver disease which will progress to cirrhosis or hepatoma, if not treated. The majority of Japanese liver patients have this disease. Hepatocyto injuries from the immune response of the host are the main compose the main hepatocyto injury caused by viruses. Cellular immunity, which was caused by CTL affected cases of schub. It was also recognaized that CD4 intervented in humoral immunity. These contained cytokines, which seemed to be positive helper T cells, as was TNF. Furthermore, CTL and Th play important roles in cases of elimination of viruses. TNF-alpha which is produced from B cells and macrophages affected this. In addition to these, analysis of immune response which was able to contain FasL became the index of severe hepatitis suggesting the analysis of immune response, which was able to contain FasL. Fas-FasL was regarded as the series which participated in the healing of hepatitis through use of steroids. |