臨牀消化器内科 Vol.13 No.2(1)


特集名 原発性硬化性胆管炎(PSC)
題名 PSCの概念と診断基準
発刊年月 1998年 02月
著者 田中 直見 筑波大学臨床医学系消化器内科
【 要旨 】 原発性硬化性胆管炎(primary sclerosing cholangitis;PSC)は現在では慢性胆汁うっ滞性肝疾患の代表的疾患であり,成人の肝移植の代表的適応疾患の一つである.PSCの診断は画像的に数珠状胆管像等の特徴的所見でなされるが,多くの疾患で類似所見を呈するので長期的経過観察による除外診断が必要となる.特異的検査法の出現が待たれる.
Theme Primary Sclerosing Cholangitis
Title Criteria and Diagnosis of Primary Sclerosing Cholangitis
Author Naomi Tanaka Department of Gastroenterology, Institute of Clinical Medicine, University of Tsukuba
[ Summary ] Primary sclerosing cholangitis (PSC), a chornic cholestatic liver disease of unknown origin, is characterized by ongoing inflammation, destruction, and fibrosis of intrahepatic and extrahepatic bile ducts. Over time, bile ducts become irregularly narrowed and obliterated, and small intrahepatic ducts disappear. Focal bile-duct dilatation proximal to areas of stricture produces a characteristic beaded appearance on cholangiography. The current criteria used to diagnose PSC are based on characteristic changes in the intrahepatic and extrahepatic biliary tree seen with ERCP or PTC. Before the diagnosis of PSC can be established, disorders that causing secondary sclerosing cholangitis must be ruled out. Laboratory tests in patients with PSC usually show a cholestatic pattern, but biochemical abbnormalities alone are never diagnostic.
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