臨牀消化器内科 Vol.12 No.12(3-2)


特集名 早期食道癌 -- 病型分類と深達度から
題名 早期食道癌の治療 (2) 内視鏡的食道粘膜切除
発刊年月 1997年 11月
著者 門馬 久美子 東京都立駒込病院内科
著者 吉田 操 東京都立駒込病院外科
【 要旨 】 食道粘膜癌に対する粘膜切除法は,小さな侵襲で根治が期待でき,治療後に機能障害を残さない優れた治療法である.治療手技には,2チャンネル法,EEMR-tube法,EMR-cap法の三つがあり,吸引を使うEEMR-tube法とEMR-cap法は,ある程度大きな粘膜が容易に切除できる.2チャンネル法は,設定した範囲が正確に,しかも必要最小限の切除ができる.粘膜切除の適応症例は,リンパ節転移や脈管侵襲のまれなm1~2癌であり,3/4周以内の粘膜切除で根治できる病変が最適症例である.合併症には,出血や穿孔,縦隔気腫があるが,大半は保存的治療にて治療可能であり,3/4周以上切除例に生じる狭窄には,ブジー拡張法が有効である.食道粘膜癌に限れば,5年生存率は,外科切除例と差がなかった.
Theme Early Esophageal cancer-from the Viewpoint of its Type and the Depth of Invasion
Title Endoscopic Mucosal Resection for Mucosal Cancer of the Esophagus
Author Kumiko Momma Department of Gastroenterology ??
Author Misao Yoshida Surgery ??
[ Summary ] Mucosal cancers of the esophagus can be treated by endoscopic mucosal resection(EMR) with minimal invasion and preservation of normal esophageal function. Three basic techniques have been established in Japan : the so-called double channel technique, the EEMR-tube technique and the EMR-cap technique. The EEMR-tube and EMR-cap techniques are available to resect larger specimens than the double channel technique. On the other hand, the double channel technique allows precise resection which achieves complete resection of a mucosal cancer by minimal defect of the esophageal mucosa. The depth of cancer invasion is one of most important indications for EMR. Mucosal cancers confined to the lamina propria mucosae are the optimal candidates for EMR, for they seldom have lymph node metastasis. The size of the lesion is also important, for esophageal stricture after EMR is frequent in cases with mucosal defects over three quarter the circumference of the esophagus. Complications of EMR such as ulcer bleeding, perforation and mediastinal emphysema were infrequent and the majority of complication could be treated conservatively. Esophageal strictures could be dilated by bouginage and none of the patients needed additional treatment. There was no significant difference of five-year survival rate between patients with mucosal cancer of the esophagus treated by EMR versus esophagectomy.
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