| [ Summary ] |
Endocrine diseases are often involved in an increase in osteoclastic bone resorption. Several hormones affect osteoclastogenesis and the regulation of its function. It is essential to understand disorders of bone metabolism in endocrine diseases. It is also necessary to understand how hormones are actually involved in osteoclastogenesis and the regulation of osteoclastic function. Hormones affecting osteoclastic bone resorption are divided into three groups ; calcium regulating hormones, sex hormones and all others. These include, parathyroid hormone, 1,25-dihydroxyvitamin D, thyroid hormone and adrenalin activate osteoclastic bone resorption factors. In contrast, calcitonin, estrogen and androgen inhibit it. Recent studies have suggested that FSH, TSH and leptin are also involved in the regulation of osteoclastic bone resorption. |